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澳门坤和试管生殖李博士专访—试管婴儿做PGS的优势,能解决试管婴儿过程中的那些问题

Macau Kun and surrogacy-Dr. Lee Interview-IVF pgs advantages, can solve the problems of IVF process   -翻译:坤和圆圆


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您可能会考虑 PGS 的一些原因:

你想优化你的 IVF 周期, 选择最有可能植入的胚胎

你经历过多次流产

你怀孕了染色体异常

你有几个不成功的 IVF 周期

你或你的伴侣进行平衡结构染色体重排                       

你想平衡你的家庭性别

 

Background on Chromosome Abnormalities

There are 23 pairs of chromosomes (for a total of 46 chromosomes) in most cells of the human body. Chromosomes contain the genetic information that tells the body how to grow and develop. Half of the chromosomes are inherited from the egg and half are inherited from the sperm. The presence of extra or missing chromosomes is called aneuploidy. Embryos that have extra or missing chromosomes often develop improperly, are less likely to implant and are more likely to miscarry. Most of these pregnancies miscarry by the end of the first trimester, but some chromosomally normal pregnancies can continue and cause disorders in live-born babies.

染色体异常背景

在人体的大多数细胞中, 23对染色体 (46条染色体)。染色体包含告诉身体如何生长和发育的基因信息。一半的染色体是从卵子中继承来的, 一半是从精子中遗传的。多余或缺失染色体的存在称为体检。有多余或缺失染色体的胚胎往往发育不当, 不易植入, 更容易流产。这些怀孕中的大多数在孕晚期流产, 但一些染色体正常怀孕可能会继续存在, 并导致出生婴儿的疾病。


Down syndrome, caused by an extra copy of chromosome 21, is the most commonly seen aneuploidy in live-born babies, although there are other aneuploidies that can result in more serious syndromes and can also be carried to term. Every couple will produce some embryos that have chromosome abnormalities. The rate increases as the woman gets older. With PGS testing, embryos are screened for extra or missing chromosomes, and those found to be chromosomally normal are preferentially transferred to the uterus for implantation.

唐氏综合征, 21号染色体的额外副本, 是最常见的体检在活出生的婴儿, 虽然有其他 aneuploidies, 可以导致更严重的综合症, 也可以进行足月。每对夫妇都会产生染色体异常的胚胎。随着妇女年龄的增长, 费率也会增加。随着 PGS 测试, 胚胎被筛查多余或缺失的染色体, 那些被发现是染色体正常的人优先转移到子宫植入。

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Kunhe and Dr. Lee expectation is that, by screening for extra or missing chromosomes prior to embryo transfer:

The chance of implantation and pregnancy can be increased.

The chance for miscarriage can be decreased.

The chance for a live birth with normal chromosomes can be increased.

坤和李博士期望的是, 在胚胎移植之前, 通过筛查多余或缺失的染色体:

植入和怀孕的机会可以增加。

流产的几率可以减少。

正常染色体的活产几率可以增加。


PGS Services at kunhe

24 CHROMOSOME PGS FOR IVF

Our aneuploidy screening platforms are comprehensive tests that examines all 24 chromosomes including autosomes 1-22, and the sex chromosomes (X, Y).

PGS 坤和助孕 的服务

24染色体 PGS 的体外受精

我们的体检筛选平台是全面的测试, 检查所有24条染色体, 包括染色体 1-22, 和性染色体 (X, Y)

 

CGH

NGS

DETECTING UNBALANCED TRANSLOCATION FOR IVF

An unbalanced translocation occurs when an embryo inherits a chromosome with extra or missing genetic material from a parent with a balanced translocation. Unbalanced translocations often result in miscarriage, or can lead to the birth of a child with intellectual disability and/or birth defects. Our microarray platform is optimized to detect chromosomal deletions and duplications larger than 1.8-3Mb in size, and to our knowledge, is the most sensitive test clinically available today. 

CGH

Ngs

体外受精的不平衡易位检测

一个不平衡的易位发生时, 胚胎继承的染色体有额外的或缺失的基因材料从父母与平衡易位。不平衡的易位往往导致流产, 或可能导致儿童的出生智力残疾和/或出生缺陷。我们的基因芯片平台被优化, 以检测染色体缺失和重叠大于 1.8-3 mb 的大小, 并对我们的知识, 是最敏感的测试, 目前临床上可用。


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